Imitrex (sumatriptan) is a prescription drug used to treat migraines and cluster headaches in adults. It is not used to prevent these conditions, only to treat symptoms when they occur. Imitrex comes in three forms: an injectable solution, a tablet, and a nasal spray. It is known to cause a range of side effects, from mild to serious. Mild side effects include fatigue, feeling unusually warm or cold, and tingling or numbness in the fingers or toes. Serious side effects include very high blood pressure, heart problems, and stroke or bleeding in the brain.
Characteristics | Values |
---|---|
Mild Side Effects | Fatigue (low energy), feeling unusually warm or cold, tingling or numbness in fingers or toes, pain, pressure or tightness in chest, throat, neck or jaw, injection site reactions |
Serious Side Effects | Very high blood pressure, problems with blood circulation, reduced blood flow to the stomach or intestines, medication overuse headache, stroke or bleeding in the brain, allergic reaction |
What You'll Learn
Imitrex and the risk of heart attack
Imitrex (sumatriptan) is a prescription drug used to treat migraines and cluster headaches in adults. It is not used to prevent these conditions, only to treat symptoms when they occur. It is available in tablet, nasal spray, and injectable forms.
Imitrex can cause mild or serious side effects, and in rare cases, it can lead to a heart attack. It is not recommended for people with risk factors for heart disease, unless a heart exam shows no problems. Risk factors for heart disease include high blood pressure, high cholesterol, and a family history of heart disease.
Serious side effects of Imitrex include:
- Heart attack and other heart problems
- Irregular heartbeat
- Stroke or bleeding in the brain
- Problems with blood circulation
- Seizures
- Very high blood pressure
If you experience any of the following symptoms of a heart attack, stop taking Imitrex and seek emergency medical help:
- Discomfort in the center of your chest that lasts for more than a few minutes, or that goes away and comes back
- Severe tightness, pain, pressure, or heaviness in your chest, throat, neck, or jaw
- Pain or discomfort in your arms, back, neck, jaw, or stomach
- Shortness of breath with or without chest discomfort
- Breaking out in a cold sweat
If you have risk factors for heart disease or any of the above heart-related conditions, it is important to consult with your doctor before taking Imitrex. They can advise you on whether this medication is safe for you and recommend alternative treatments if necessary.
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Imitrex and serotonin syndrome
Imitrex (sumatriptan) is a prescription drug used to treat migraines and cluster headaches. It is a type of drug called a triptan, which works by stimulating serotonin receptors in the brain. While Imitrex is an effective treatment for many people, it can cause a range of side effects, from mild to serious. One of the serious side effects that has been reported with Imitrex is serotonin syndrome.
Serotonin syndrome is a rare but potentially life-threatening condition that can occur when there is too much serotonin in the body. Serotonin is a chemical in the brain and nervous system that is important for maintaining good mental health and other bodily functions. However, when there is too much serotonin, it can lead to negative effects such as confusion, loss of consciousness, high heart rate, hallucinations, high body temperature, nausea, vomiting, and diarrhea.
The risk of developing serotonin syndrome with Imitrex is highest when it is used in combination with other medications that increase serotonin levels, such as selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs). In 2006, the US Food and Drug Administration (FDA) issued an alert warning about the potential risk of serotonin syndrome with the combined use of SSRIs or SNRIs and triptans like Imitrex. The FDA recommended that patients taking these medications be informed of the possibility of serotonin syndrome and carefully monitored.
While serotonin syndrome was not reported in clinical trials of Imitrex tablets, nasal spray, or injection, it is a known side effect of triptans. The symptoms of serotonin syndrome can include loss of coordination, agitation, hallucinations, high body temperature, nausea, vomiting, and diarrhea. If left untreated, serotonin syndrome can lead to more serious complications such as seizures, coma, rhabdomyolysis, and disseminated intravascular coagulation.
If you are taking Imitrex and experience any symptoms of serotonin syndrome, it is important to seek medical help right away. Treatment for serotonin syndrome typically involves discontinuing the medications that are increasing serotonin levels and providing supportive care to manage symptoms.
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Imitrex and pregnancy
Imitrex (sumatriptan) is a prescription drug used to treat migraines and cluster headaches. It is not known whether Imitrex is safe to use during pregnancy. Animal studies have found that the drug could cause congenital anomalies when given to pregnant females, but it is unclear whether the same effects would occur in humans.
A pregnancy registry collected data on the health of babies exposed to sumatriptan in the womb between 1996 and 2012. This data did not raise concerns about a heightened risk of congenital anomalies. Population studies have also examined the rate of congenital anomalies in babies born to mothers who took sumatriptan during pregnancy, and found no increased risk.
However, some studies have suggested a small increase in the chance of certain pregnancy-related problems, including preeclampsia, preterm birth, low birth weight, and heavy bleeding after delivery if sumatriptan was used late in pregnancy. It is important to note that some of these complications have also been associated with migraines during pregnancy, so it is difficult to determine whether the medication, the condition being treated, or other factors are the cause of these complications.
If you are pregnant or planning to become pregnant, it is important to talk to your doctor about the risks and benefits of taking Imitrex.
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Imitrex and breastfeeding
Imitrex (sumatriptan) is a prescription drug used to treat migraine and cluster headaches in adults. It can be taken in tablet, nasal spray, or injection form. While it is known that Imitrex can pass into breast milk, it is unclear whether it could cause side effects in a child who is breastfed. The manufacturer recommends withholding breastfeeding for 12 hours after taking a dose of Imitrex to minimise infant exposure to the drug.
Some studies have reported painful, burning nipples and breast pain in women who took sumatriptan and other triptans while nursing. This was occasionally accompanied by a decrease in milk production. However, these side effects generally subsided as the drug was eliminated from the body. It is suggested that triptans may cause vasoconstriction of the arteries in the breast, nipples, and the arteries surrounding the alveoli and milk ducts, resulting in a painful sensation and milk ejection reflex.
Sumatriptan is not well absorbed by the infant's stomach, and the amount ingested by the infant is small due to its low levels in breast milk. According to the manufacturer, avoiding breastfeeding for 12 hours after taking a dose can minimise infant exposure. Sumatriptan is not expected to cause adverse effects in most breastfed infants, but it is still recommended to consult a healthcare provider for specific breastfeeding questions and concerns.
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Imitrex and allergic reaction
Imitrex (sumatriptan) is a prescription drug used to treat migraines and cluster headaches. It can cause a range of side effects, from mild to serious, including allergic reactions.
An allergic reaction to Imitrex is rare but possible. Symptoms of a mild allergic reaction can include:
- Flushing (temporary warmth, redness, or deepening of skin colour)
- Swelling under the skin, typically on the eyelids, lips, hands, or feet
- Swelling of the mouth, tongue, or throat, which can cause difficulty breathing
If you experience mild symptoms of an allergic reaction, such as a mild rash, call your doctor right away. They may suggest treatments to manage your symptoms, such as antihistamines or hydrocortisone cream.
If you experience severe symptoms of an allergic reaction, such as swelling or difficulty breathing, call 911 or your local emergency number immediately. These symptoms could be life-threatening and require immediate medical attention.
If your doctor confirms a serious allergic reaction to Imitrex, they will likely recommend discontinuing the medication and switching to a different treatment.
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Frequently asked questions
Imitrex may rarely cause serious and, sometimes, fatal cerebrovascular problems (disorders related to the brain and its blood vessels), including stroke. Symptoms of a stroke can include:
- Drooping on one side of the face
- Slurred speech or trouble speaking
- Sudden weakness or numbness on one side of the body
- Severe headache that occurs suddenly
If you experience any symptoms of a stroke, call 911 or your local emergency number right away. A stroke is a medical emergency.
Your risk of a stroke may be higher if you have certain risk factors, including:
- Older age
- High cholesterol
- High blood pressure
- Obesity
- Diabetes
- Smoking
- A family history of heart disease