
Doxycycline is a tetracycline antibiotic that is used to treat a variety of bacterial infections. It is also used to prevent malaria and treat acne and rosacea. It is generally well-tolerated, but like all medicines, it can cause side effects.
There have been rare reports of doxycycline causing serious side effects such as intracranial hypertension and increased risk of ischemic stroke. It may also increase the risk of intracranial hypertension in women who are overweight or have a history of the condition. Additionally, doxycycline has been found to impair cardiac mitochondrial and contractile function, which could potentially lead to cardiac dysfunction.
It is important to be aware of the potential side effects of doxycycline and to seek medical advice if any symptoms occur.
Characteristics | Values |
---|---|
--- | --- |
Common side effects | Feeling sick, being sick, skin being sensitive to sunlight |
Serious side effects | Bruising or bleeding you cannot explain, a sore throat, high temperature and feeling tired or generally unwell, diarrhoea, ringing or buzzing in your ears, pale poo and dark pee, joint or muscle pain since starting doxycycline, severe headaches, vomiting and problems with your vision, a fingernail that starts coming away from its base, a sore or swollen mouth, lips or tongue, severe pain in your stomach, with or without bloody diarrhoea, nausea and vomiting, difficulty or pain when you swallow, a sore throat, acid reflux, a smaller appetite or chest pain which gets worse when you eat |
Antibiotics/antifungal agents | Doxycycline, amoxicillin, pivmecillinam, phenoxymethylpenicillin, trimethoprim, ciprofloxacin, oral nystatin, methenamine, chloramphenicol |
Cardiovascular drugs | Several antithrombotic agents, metoprolol, simvastatin, isosorbide mononitrate |
Psychoactive medications | Mirtazapine, levomepromazine, zopiclone |
What You'll Learn
- Doxycycline can cause serious side effects, including an increased risk of intracranial hypertension
- Doxycycline may cause an allergic reaction, including symptoms such as a swollen throat, wheezing, and gasping for air
- Doxycycline may cause an increased risk of stroke, particularly in those with pre-existing metabolic vulnerabilities
- Doxycycline may cause an increased risk of arrhythmias and irregular contractions in the heart
- Doxycycline may cause an increased risk of nausea and vomiting
Doxycycline can cause serious side effects, including an increased risk of intracranial hypertension
Doxycycline is an antibiotic that can be used to treat a variety of infections caused by certain types of bacteria. It can also be used to treat or prevent anthrax, plague, and tularemia, and to prevent malaria. It is also used to treat acne and rosacea.
In rare cases, doxycycline can cause severe intracranial hypertension, which can lead to permanent vision loss. Symptoms of intracranial hypertension include severe headaches, vomiting, blurred vision, and difficulty breathing or swallowing. It is important to seek medical advice if you experience any of these symptoms while taking doxycycline.
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Doxycycline may cause an allergic reaction, including symptoms such as a swollen throat, wheezing, and gasping for air
Doxycycline is an antibiotic medication that can be used to treat bacterial infections, acne, rosacea, and malaria. It can also be used to treat or prevent swelling of the tissue around the teeth (periodontitis).
Like all medicines, doxycycline may cause side effects, although not everyone gets them. In rare cases, doxycycline can cause a serious allergic reaction known as anaphylaxis. This may include symptoms such as:
- Swelling of the lips, mouth, throat, or tongue
- Difficulty breathing, wheezing, or gasping for air
- Tightness in the chest or throat
- Skin, tongue, or lips turning blue, grey, or pale
- Feeling very confused, drowsy, or dizzy
If you experience any of these symptoms, seek immediate medical attention.
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Doxycycline may cause an increased risk of stroke, particularly in those with pre-existing metabolic vulnerabilities
Doxycycline is a tetracycline antibiotic that is used to treat a variety of bacterial infections, as well as acne and rosacea. It is also used to prevent malaria and treat Lyme disease.
Doxycycline has been associated with an increased risk of stroke, particularly in those with pre-existing metabolic vulnerabilities. This risk is thought to be related to the drug's inhibitory effect on mitochondrial protein synthesis, which can lead to a reduction in mitochondrial function and an increase in cytosolic calcium concentration, making cardiomyocytes more vulnerable to arrhythmias.
In addition to its effects on mitochondrial function, doxycycline can also cause a range of other side effects, including nausea, vomiting, skin sensitivity to sunlight, and allergic reactions. It is important for individuals taking doxycycline to be aware of these potential risks and to seek medical advice if they experience any unusual symptoms.
Doxycycline has been found to impair cardiac mitochondrial and contractile function, which may contribute to an increased risk of stroke. Studies have shown that doxycycline can cause a mitonuclear protein imbalance, leading to reduced maximal mitochondrial respiration, particularly with complex I substrates. This can result in a shift away from oxidative phosphorylation towards glycolysis and fragmented mitochondria. These changes can affect cardiac contractility, leading to increased diastolic calcium concentration and a higher arrhythmicity index, which may increase the risk of stroke.
Furthermore, doxycycline has been associated with intracranial hypertension, which can also increase the risk of stroke. This condition can cause symptoms such as headaches, blurred vision, and diplopia, and can lead to permanent loss of vision if left untreated. Therefore, it is important for individuals taking doxycycline, especially those with pre-existing metabolic vulnerabilities, to be aware of the potential risks and to seek medical advice if they experience any unusual symptoms.
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Doxycycline may cause an increased risk of arrhythmias and irregular contractions in the heart
Doxycycline is a tetracycline antibiotic that impairs cardiac mitochondrial and contractile function. It acts by inhibiting bacterial protein translation, and given the bacterial ancestry of mitochondria, it also reduces mitochondrial function. This results in an increased risk of arrhythmias and irregular contractions in the heart.
In cultured H9C2 cardiomyoblasts, adult rat cardiomyocytes, Drosophila and mice, doxycycline caused a mitonuclear protein imbalance, reduced maximal mitochondrial respiration, and fragmented mitochondria.
In adult rat cardiomyocytes, doxycycline increased the diastolic calcium concentration and arrhythmicity index. Systolic and diastolic dysfunction were also observed in mice treated with doxycycline.
Overall, doxycycline impairs mitochondrial function and causes cardiac dysfunction, leading to an increased risk of arrhythmias and irregular contractions in the heart.
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Doxycycline may cause an increased risk of nausea and vomiting
Doxycycline is a generic drug used to treat various bacterial infections, skin conditions, and malaria prevention. It is available in many brand-name versions, including Doryx, Doryx MPC, Acticlate, Oracea, and Vibramycin.
Doxycycline can cause certain side effects, some of which are more common than others. Nausea and vomiting are among the more common side effects of the drug, occurring in around 1 in 10 people. It is recommended that doxycycline is taken with milk or food to lower the risk of nausea and vomiting.
Mild side effects of doxycycline include swelling of the tongue or digestive tract, difficulty swallowing, fungal infections, and mild allergic reactions.
Serious side effects of doxycycline are rare but may include severe allergic reactions, serious skin rashes, and severe headaches, vomiting, and problems with vision, which could be signs of pressure around the brain.
If you experience any serious side effects while taking doxycycline, call your doctor right away or seek immediate medical care if symptoms are life-threatening.
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Frequently asked questions
Doxycycline is a tetracycline antibiotic that can cause several side effects, including an increased risk of intracranial hypertension (pseudotumor cerebri). This condition involves increased pressure in the skull, which can lead to headaches, blurred vision, diplopia, back and neck pain, and other symptoms. While doxycycline has been associated with intracranial hypertension, it is not clear if it directly causes strokes. However, doxycycline can have negative effects on cardiac mitochondrial and contractile function, which may indirectly increase the risk of stroke.
The symptoms of a stroke can vary but often include sudden numbness or weakness in the face, arm, or leg, especially on one side of the body; confusion or difficulty speaking or understanding speech; trouble seeing in one or both eyes; difficulty walking, dizziness, or loss of balance or coordination; and severe headache with no known cause. It is important to seek immediate medical attention if you experience any of these symptoms, as prompt treatment is crucial for improving the chances of recovery.
If you or someone near you is exhibiting signs of a stroke, call emergency services immediately. Getting medical attention as soon as possible is crucial for improving the chances of recovery. Do not wait to see if the symptoms go away, as prompt treatment is essential.