Ibsrela: A Laxative Solution For Ibs?

Ibsrela is a brand-name medication used to treat irritable bowel syndrome with constipation (IBS-C) in adults. It is not recommended for children under the age of 18 due to the risk of serious dehydration. Ibsrela contains the active ingredient tenapanor, which works by blocking the absorption of sodium from food, allowing more water to flow into the digestive tract and softening stool. This can increase the frequency of bowel movements and may cause diarrhea as a side effect. However, it is not a laxative.

Ibsrela's active ingredient, tenapanor, and how it works

Ibsrela is a brand-name medication that is used to treat irritable bowel syndrome with constipation (IBS-C) in adults. The active ingredient in Ibsrela is tenapanor, which belongs to a class of drugs known as sodium/hydrogen exchanger 3 (NHE3) inhibitors.

Tenapanor works by blocking the NHE3 receptor, a type of protein found on the surface of cells in the small intestine and colon. This receptor normally regulates how much sodium (salt) is absorbed from the diet into the body. By inhibiting NHE3, tenapanor reduces the amount of sodium absorbed by the body, leading to increased water content in the intestines. This helps to soften stools and promote bowel movements, thereby relieving constipation.

In addition, tenapanor may also work by reducing the sensitivity of the digestive tract, which can help alleviate abdominal pain associated with IBS. Furthermore, it may also decrease the permeability of the digestive tract lining, reducing the "leaky gut" effect that is thought to contribute to IBS.

Ibsrela is typically taken orally as a 50 mg tablet twice daily, and it starts working soon after the first dose. It is important to note that Ibsrela is not recommended for children due to the risk of serious dehydration.

Dosage instructions and frequency

Ibsrela is a brand-name medication that is prescribed for irritable bowel syndrome with constipation (IBS-C) in adults. It is not available in a generic version. It comes as an oral tablet in one strength: 50 milligrams (mg).

The typical dosage for Ibsrela is 50 mg taken by mouth twice per day. You should take the first dose right before breakfast or your first meal of the day, and the second dose right before dinner. This timing helps Ibsrela work effectively, as it should be taken before food. Taking Ibsrela with food may also help the drug work more effectively.

If you miss a dose, skip the missed dose and take the next dose at the regular time. Do not take two doses at the same time to make up for the missed dose.

Ibsrela is meant to be a long-term treatment. If you and your doctor determine that Ibsrela is safe and effective for you, you will likely take it long-term.

Side effects and what to do if they occur

Ibsrela may cause mild to serious side effects. It is important to note that side effects of a drug can depend on other health conditions you have and other medications you take. Your doctor or pharmacist can tell you more about the potential side effects of Ibsrela and suggest ways to help reduce them.

Mild side effects

Mild side effects of Ibsrela may include:

• Abdominal pressure or swelling
• Mild allergic reaction

Mild side effects of many drugs may go away within a few days to a couple of weeks. But if they become bothersome, talk with your doctor or pharmacist.

Serious side effects

Serious side effects from Ibsrela can occur, but they are not common. If you experience any of the following serious side effects, call your doctor right away. But if you think you’re having a medical emergency, call 911 or your local emergency number.

Serious side effects of Ibsrela that have been reported include:

• Boxed warning: risk of serious dehydration in certain children
• Severe allergic reaction

While allergic reaction wasn’t reported in studies of Ibsrela, it can still happen. Symptoms of a mild allergic reaction can include:

Flushing (temporary warmth, redness, or deepening of skin colour)

A more severe allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include:

• Swelling under your skin, usually in your eyelids, lips, hands, or feet
• Swelling of your tongue, mouth, or throat, which can cause trouble breathing

Call your doctor right away if you have an allergic reaction to Ibsrela. But if you think you’re having a medical emergency, call 911 or your local emergency number.

Overdose

If you think you’ve taken too much of this drug, call your doctor. You can also call America’s Poison Centers at 800-222-1222 or use its online tool. However, if your symptoms are severe, call 911 or your local emergency number, or go to the nearest emergency room right away.

Symptoms of an overdose can include severe diarrhea, which may lead to dehydration.

Ibsrela's interaction with other drugs

Ibsrela is known to interact with several other medications. It is important to inform your doctor about all prescription, over-the-counter, and other drugs you take, as well as any vitamins, herbs, and supplements you use. This can help you avoid potential interactions.

Ibsrela may decrease the effects of enalapril (Vasotec, Epaned). It is not known to interact with specific herbs, supplements, or foods. Alcohol is also not known to interact with Ibsrela, and it is likely safe to consume alcohol while taking the medication. However, it is always best to consult with your doctor or pharmacist about the amount of alcohol that is safe to consume while taking Ibsrela.

Before taking Ibsrela, it is important to discuss your health history with your doctor. Ibsrela may not be suitable for you if you have certain medical conditions or other factors that affect your health. Be sure to inform your doctor if any of the following apply to you:

• Bowel obstruction (blockage)
• Chronic kidney disease
• Past allergic reaction to Ibsrela or a similar drug

Precautions and warnings for use

Ibsrela is a prescription medication used to treat irritable bowel syndrome with constipation (IBS-C) in adults. It is not suitable for children under 6 years old and is not recommended for those aged 6 to 18 years old due to the risk of harm, particularly severe dehydration.

Pre-existing Conditions

Before taking Ibsrela, inform your doctor if you have any pre-existing medical conditions, especially bowel obstruction (blockage) or intestinal obstruction. It is also important to disclose any history of allergic reactions to this drug or similar medications.

Pregnancy and Breastfeeding

The safety of Ibsrela during pregnancy and breastfeeding is not fully established. Consult your doctor to discuss the risks and benefits of using Ibsrela if you are pregnant or planning to become pregnant. Additionally, it is unknown if Ibsrela passes into breast milk, so discuss alternative feeding methods with your doctor if you are breastfeeding or planning to breastfeed.

Drug Interactions

Drug interactions can alter how your medications work and increase the risk of side effects. Inform your doctor about all the medications you are currently taking, including prescription drugs, over-the-counter medicines, vitamins, herbal supplements, and any other substances. This information will help your doctor assess the potential for drug interactions and make adjustments as needed.

Allergies

Inform your doctor or pharmacist if you have any known allergies, including allergies to Ibsrela or any of its inactive ingredients. This medication may contain inactive ingredients that can cause allergic reactions or other issues. Consult your pharmacist for detailed information about the ingredients.

Surgery

If you are scheduled for surgery, inform your doctor or dentist about all the products you are using, including prescription drugs, non-prescription medications, and herbal supplements.

Side Effects

Ibsrela may cause mild or serious side effects. The most common side effect is diarrhea, which can sometimes be severe. If you experience severe diarrhea, stop taking Ibsrela and contact your doctor immediately. Other possible side effects include swelling or a feeling of fullness or pressure in your abdomen (distension).

If you experience any other side effects not listed, contact your doctor or pharmacist for medical advice. Report any side effects to the FDA or relevant authorities in your country.

Dosage

Take Ibsrela exactly as directed by your doctor. Typically, it is taken orally, twice daily, immediately before your first meal of the day and before dinner. Swallow the tablets whole; do not crush or chew them. If you miss a dose, skip the missed dose and take the next dose at the regular time. Do not double the dose to catch up.

Storage

Store Ibsrela tablets at room temperature, between 68°F and 77°F (20°C and 25°C), in their original container. Protect them from moisture and keep the container tightly closed in a dry place.

Frequently asked questions